Genomic signatures of adaptation
Our research focuses on population genomics, analyzing genomic diversity and adaptive potential. We have developed browsers like PopFly and PopHuman, which provide comprehensive data on Drosophila melanogaster and the human genome. These browsers enable the identification of genomic regions involved in adaptive selection and offer tests for selection detection. Additionally, we aim to develop a new statistical approach for estimating the fraction of adaptive substitutions in any genomic region, regardless of linked selective events or demographic scenarios. On a larger scale, we plan to study Vibrio parahaemolyticus as a model organism to understand population dynamics and adaptation to climate change. By expanding our genome collection to 10,000 samples representing various ecological niches and continents, we aim to create a valuable resource for defining population structure and identifying targets of positive selection within V. parahaemolyticus populations, particularly those undergoing global expansion due to climate change.
Subobjectives
Interpreting signatures of recent adaptation in the human genome
Searching signatures of genomic adaptation in Vibrio
Developing a new statistical method to estimate adaptive substitutions
Results
Conferences
X Jornada científica del Departament de Genètica i de Microbiologia,
Facultat de Biociències de la UAB, June 19, 2023
Unveiling genetic variation patterns in simulated altruistic populationsusing deep learning
Noah Jornet Calomarde, Sònia Casillas, Antonio Barbadilla and Oscar Lao.
Poster